Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

Article ID	Journal	Published Year	Pages	File Type
3294134	Gastroenterology	2012	15 Pages	PDF

Abstract

Aspirin is an inhibitor of mTOR and an activator of AMPK, targeting regulators of intracellular energy homeostasis and metabolism. These could contribute to its protective effects against development of CRC.

Keywords

ADP S6 kinase 1 human antigen R S6 ribosomal protein NDRG1 4E-BP1 eIF4E S6K1 LC3 AMPK mTOR NSAID MEF mRNA ACC PI3K PBS eukaryotic translation initiation factor 4E messenger RNA Small interfering RNA siRNA Adenosine Triphosphate ATP adenosine diphosphate adenosine monophosphate–activated protein kinase acetyl-CoA carboxylase Oncogene nonsteroidal anti-inflammatory drug light chain 3 Colorectal cancer Colon cancer Tumor suppressor phosphoinositide-3-kinase Phosphate-buffered saline mouse embryonic fibroblast Mechanistic target of rapamycin Chemoprevention HuR CRC