| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294137 | Gastroenterology | 2012 | 16 Pages |
Abstract
The transporter Zip14 mediates hepatic uptake of zinc during liver regeneration and for hepatocyte proliferation. These findings indicate that zinc transporter activity regulates liver tissue growth by sequestering zinc. Reagents that regulate ZIP14 activity might be developed as therapeutics to promote liver regeneration in patients with chronic liver disease.
Keywords
TNFPCNAZnTPTP1BLPSZNDHGFZNAERKPHxProliferating Cell Nuclear Antigeninterleukininterleukin-6Tissue regenerationLiver regenerationBrdUanalysis of varianceANOVAZinc transporterHepatocyte growth factortumor necrosis factorlipopolysaccharidemicronutrientzinc supplementwild-typeSignal transductionPartial hepatectomypolymerase chain reactionPCRProtein tyrosine phosphatase 1BExtracellular signal–regulated kinase
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Authors
Tolunay Beker Aydemir, Harry S. Sitren, Robert J. Cousins,