Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E

Article ID	Journal	Published Year	Pages	File Type
3294139	Gastroenterology	2012	14 Pages	PDF

Abstract

ZHX2 inhibits HCC cell proliferation by preventing expression of Cyclins A and E, and reduces growth of xenograft tumors in mice. Loss of nuclear ZHX2 might be an early step in the development of HCC.

Keywords

CCK-8 NF-YA GPC3 MVD NLS mRNA eGFP shRNA HCC messenger RNA Small interfering RNA short hairpin RNA siRNA α-fetoprotein chromatin immunoprecipitation Cho Chinese Hamster Ovary microvascular density AFP Carcinogenesis nuclear localization signal Mouse model hemagglutinin polymerase chain reaction PCR enhanced green fluorescent protein CHiP Hepatocellular carcinoma Glypican 3

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E

Authors

Xuetian Yue, Zhenyu Zhang, Xiaohong Liang, Lifen Gao, Xiaoning Zhang, Di Zhao, Xiao Liu, Hongxin Ma, Min Guo, Brett T. Spear, Yaoqin Gong, Chunhong Ma,