| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294212 | Gastroenterology | 2010 | 11 Pages |
Abstract
MCD feeding causes an integrated stress response in the liver rather than a classic unfolded protein response. This stress response does not by itself lead to liver injury. CHOP, despite its identity as a mediator of stress-related cell death, does not play a central role in the pathogenesis of MCD-mediated liver disease.
Keywords
XBP-1HRITRB3MCDBcl-xLGRP94ATF6eIF2αApoB100IRE1UPRcJun N-terminal kinaseGCN2Ero1ISRImmunoglobulin-binding proteinB-cell lymphoma extra-largeMCsERADEukaryotic initiation factor-2αJnkinositol-requiring protein-1BiPC/EBP homologous proteinapolipoprotein B100Steatohepatitisnonalcoholic steatohepatitisEndoplasmic reticulum stressER-Associated DegradationTerminal deoxynucleotidyl transferase dUTP nick end labelingSteatosisTUNELCHOPendoplasmic reticulumactivating transcription factor-6Nash wild-typetribbles homolog 3Integrated stress responseUnfolded protein responseglucose-regulated protein 94PERK
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Authors
Russell K. Jr, Jim S. Yan, James P. Grenert, Jacquelyn J. Maher,