A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function

Article ID	Journal	Published Year	Pages	File Type
3294676	Gastroenterology	2013	12 Pages	PDF

Abstract

Gluten alters bowel barrier functions in patients with IBS-D, particularly in HLA-DQ2/8-positive patients. These findings reveal a reversible mechanism for the disorder. Clinical trials.gov NCT01094041.

Keywords

granulocyte-macrophage colony–stimulating factor IBS-D ZO-1 PBMC mRNA GAPDH GCD IBS GFD GM-CSF messenger RNA Tight junction ITT Transit small bowel Gluten-free diet Peripheral blood mononuclear cell diarrhea-predominant irritable bowel syndrome irritable bowel syndrome Cytokines zonula occludens 1 confidence interval granulocyte colony–stimulating factor G-CSF intention-to-treat Immunity Permeability polymerase chain reaction PCR glyceraldehyde 3-phosphate dehydrogenase

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function

Authors

Maria I. Vazquez-Roque, Michael Camilleri, Thomas Smyrk, Joseph A. Murray, Eric Marietta, Jessica O'Neill, Paula Carlson, Jesse Lamsam, Denise Janzow, Deborah Eckert, Duane Burton, Alan R. Zinsmeister,