Transforming Growth Factor-Î² Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1

Article ID	Journal	Published Year	Pages	File Type
3294690	Gastroenterology	2013	17 Pages	PDF

Abstract

TGF-Î² promotes development of HCC in Tak1ÎHep mice by inducing hepatocyte apoptosis and compensatory proliferation during early phases of tumorigenesis, and inducing expression of anti-apoptotic, pro-oncogenic, and angiogenic factors during tumor progression.

Keywords

NF-κB TNF N-nitrosodiethylamine TGFBR2 c-Jun-N-terminal kinase TAK1 TGF IKK Den ALT CTGF GFP Jnk HCC IκB kinase Alanine aminotransferase Oncogene interleukin terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling transforming growth factor TUNEL Liver cancer Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Connective tissue growth factor tumor necrosis factor Nuclear factor–κB Mouse model wild-type Signal transduction green fluorescent protein Hepatocellular carcinoma