| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294691 | Gastroenterology | 2013 | 11 Pages |
Abstract
Based on analyses of knockout mice, mTORC1 and Akt have different yet synergistic effects during the development of liver tumors in mice.
Keywords
tuberous sclerosis complex 1PCNAPI3KTSC1EGFPDGFRBSox9mTORC1DMEMFGFR1FBSDKOICCALBqRT-PCRDulbecco's modified Eagle MediumHCCv-akt murine thymoma viral oncogene homolog 1AlbuminProliferating Cell Nuclear AntigenAktGene disruptionImmunohistochemistryIHCDouble knock-outLiver cancerfetal bovine serumepidermal growth factorphosphatase and tensin homologphosphatidylinositide 3-kinaseMouse modelSignal transductionMammalian target of rapamycin complex 1quantitative reverse-transcription polymerase chain reactionplatelet-derived growth factor receptor βPtenHepatocellular carcinomaIntrahepatic cholangiocarcinomaFibroblast growth factor receptor 1
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Heidi L. Kenerson, Matthew M. Yeh, Machiko Kazami, Xiuyun Jiang, Kimberly J. Riehle, Rebecca L. McIntyre, James O. Park, Steve Kwon, Jean S. Campbell, Raymond S. Yeung,