| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294694 | Gastroenterology | 2013 | 21 Pages |
Abstract
EZH2 is up-regulated in PDAC samples from patients and silences miR-218. MicroRNA-218 prevents proliferation of PDAC cells in culture, and tumor growth and metastasis in nude mice. MicroRNA-218 reduces levels of UDP-glycosyltransferase, which is associated with the metastatic potential of PDAC tumors in mice and progression of human PDAC.
Keywords
HPDEPRC2histone 3 lysine 27 trimethylationH3K27me3DZNepEZH25-AzacytidineDnmtqRT-PCRMIRshRNA3-Deazaneplanocin A3′-UTR3′-untranslated regionDNA methyltransferaseSmall interfering RNAshort-hairpin RNAsiRNAPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaEpigeneticGene regulationPancreatic cancerMicroRNAquantitative reverse transcription polymerase chain reactionpolycomb repressive complex 2
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Authors
Chi Han Li, Ka-Fai To, Joanna Hung-Man Tong, Zhangang Xiao, Tian Xia, Paul B.S. Lai, Sheung Ching Chow, Yin-Xin Zhu, Stephen L. Chan, Victor E. Marquez, Yangchao Chen,