Article ID Journal Published Year Pages File Type
3294758 Gastroenterology 2009 9 Pages PDF
Abstract
These data indicate that basal tone and acetylcholine-induced force generation depend on signaling through the PKC pathway in human IAS; PKC-mediated force generation is independent of the Rho/ROCK pathway. This human IAS 3DBR model can be used to study the pathophysiology associated with IAS malfunctions.
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Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
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Bioengineered Internal Anal Sphincter Derived From Isolated Human Internal Anal Sphincter Smooth Muscle Cells
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