Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response

Article ID	Journal	Published Year	Pages	File Type
3294857	Gastroenterology	2009	16 Pages	PDF

Abstract

Our results reveal that LSECtin is a novel regulator of T cells and expose a crucial mechanism for hepatic T-cell immune suppression, perhaps opening up a new approach for treatment of inflammatory diseases in the liver.

Keywords

mGl DC-SIGN CLR Phorbol-12-myristate-13-acetate PBL CRD NF-κβ OVA PGK TCr EGTA PBMC L-SIGN mAb TNF nuclear factor-Κβ PMA LSEC Quantitative PCR q-PCR siRNA Monoclonal antibody Ovalbumin interferon IFN interleukin carbohydrate recognition domain small interfering SARS liver sinusoidal endothelial cell Peripheral blood mononuclear cell Dendritic cell severe acute respiratory syndrome tumor necrosis factor phosphoglycerate kinase peripheral blood lymphocyte polymerase chain reaction PCR T-cell receptor C-type lectin receptors

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response

Authors

Li Tang, Juntao Yang, Wanli Liu, Xiaoming Tang, Jie Chen, Dianyuan Zhao, Min Wang, Feng Xu, Yantao Lu, Biao Liu, Qihong Sun, Lingqiang Zhang, Fuchu He,