Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3294888 | Gastroenterology | 2011 | 18 Pages |
Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that act as sensors for a broad range of natural and synthetic ligands and regulate several key hepatic functions including bile acid homeostasis, bile secretion, lipid and glucose metabolism, as well as drug deposition. Moreover, NRs control hepatic inflammation, regeneration, fibrosis, and tumor formation. Therefore, NRs are key for understanding the pathogenesis and pathophysiology of a wide range of hepatic disorders. Finally, targeting NRs and their alterations offers exciting new perspectives for the treatment of liver diseases.
Keywords
HSCPSCNAFLDSREBP1TGR5VLDLUDCAPBCnonalcoholic steatohepatitisUrsodeoxycholic acidNonalcoholic fatty liver diseaseHepatic stellate cellsPrimary biliary cirrhosisvery low-density lipoproteinNash sterol regulatory element-binding protein 1Bile salt export pumpPrimary sclerosing cholangitisshort heterodimer partnerconstitutive androstane receptorEstrogen receptor alphaVitamin D receptorPregnane X receptor
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Authors
Michael Trauner, Emina Halilbasic,