| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294914 | Gastroenterology | 2011 | 19 Pages |
Abstract
Methylation patterns can be analyzed to determine the rates of recent clonal expansion of stem cells, but determination of clonality over many decades is restricted by epigenetic drift. We developed a technique to follow changes in intestinal stem cell dynamics in human epithelial tissues that might be used to study premalignant disease.
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Gastroenterology
Authors
Trevor A. Graham, Adam Humphries, Theodore Sanders, Manuel Rodriguez-Justo, Paul J. Tadrous, Sean L. Preston, Marco R. Novelli, Simon J. Leedham, Stuart A.C. McDonald, Nicholas A. Wright,