| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294915 | Gastroenterology | 2011 | 16 Pages |
Abstract
There is evidence for a distinct clonal evolution from metaplasia to dysplasia in the human stomach. By field cancerization, a single clone can expand to form an entire dysplastic lesion. Over time, this field appears to become genetically diverse, indicating that gastric cancer can arise from a subclone of the founder mutation.
Keywords
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Gastroenterology
Authors
Lydia Gutierrez-Gonzalez, Trevor A. Graham, Manuel Rodriguez-Justo, Simon J. Leedham, Marco R. Novelli, Laura J. Gay, Tania Ventayol-Garcia, Alicia Green, Ian Mitchell, David L. Stoker, Sean L. Preston, Shigeki Bamba, Eiji Yamada, Yuuki Kishi,