Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3294918 | Gastroenterology | 2011 | 11 Pages |
Abstract
Pancreatic inflammation significantly increased the expression and functional properties of TRPV1 and TRPA1, as well as the excitability of pancreatic sensory neurons in vagal and spinal pathways. TRP channel antagonists acted synergistically to reverse pancreatic inflammation and associated pain behaviors; reagents that target interactions between these channels might be developed to reduce pain in patients with acute pancreatitis.
Keywords
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Gastroenterology
Authors
Erica S. Schwartz, Julie A. Christianson, Xiaowei Chen, Jun-Ho La, Brian M. Davis, Kathryn M. Albers, G.F. Gebhart,