| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3295456 | Gastroenterology | 2012 | 23 Pages |
Abstract
Dietary cholesterol aggravates liver fibrosis because free cholesterol accumulates in HSCs, leading to increased TLR4 signaling, down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor, and sensitization of HSC to TGFβ. This pathway might be targeted by antifibrotic therapies.
Keywords
TNFαTLR4BDLHSCsαSMACCl4ALTTGFβNPC1mRNABmp and activin membrane-bound inhibitorNiemann-Pick Type C1AcLDLLPSmessenger RNAAlanine aminotransferaseDyslipidemiaα-smooth muscle actinBambiLiver diseaseTransforming growth factor βtriglyceridetumor necrosis factor-αHepatic stellate cellslipopolysaccharideMouse modelknock-outwild-typebile duct ligationCarbon tetrachlorideCholesterol esterHigh cholesteroltotal cholesterolfree cholesterolToll-like receptor 4
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Authors
Toshiaki Teratani, Kengo Tomita, Takahiro Suzuki, Tetsuya Oshikawa, Hirokazu Yokoyama, Katsuyoshi Shimamura, Susumu Tominaga, Sadayuki Hiroi, Rie Irie, Yoshikiyo Okada, Chie Kurihara, Hirotoshi Ebinuma, Hidetsugu Saito, Ryota Hokari, Kazuo Sugiyama,