| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3295517 | Gastroenterology | 2011 | 13 Pages |
Abstract
Colitis and intestinal inflammation in IL10â/â mice results from IL-13Rα2-mediated attenuation of IL-13 activity. In the absence of IL-13Rα2, IL-13 suppresses proinflammatory Th1 and Th17 responses. Reagents that block the IL-13 decoy receptor IL-13Rα2 might be developed for inflammatory bowel disease associated with increased levels of IFN-γ and IL-17.
Keywords
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Authors
Mark S. Wilson, Thirumalai R. Ramalingam, Aymeric Rivollier, Kevin Shenderov, Margaret M. Mentink-Kane, Satish K. Madala, Allen W. Cheever, David Artis, Brian L. Kelsall, Thomas A. Wynn,