Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

Article ID	Journal	Published Year	Pages	File Type
3295521	Gastroenterology	2011	19 Pages	PDF

Abstract

BMP4 promotes terminal differentiation, apoptosis, and chemosensitization of CRC-SCs in tumors that do not have simultaneous mutations in Smad4 and constitutive activation of PI3K. BMP4 might be developed as a therapeutic agent against cancer stem cells in advanced colorectal tumors.

Keywords

ALDH GSK MSI BMPR APC CSC MSS SMAD RT-PCR Sfrp4 FBS 5-FU PI3K Akt/Protein kinase B adenomatous polyposis coli aldehyde dehydrogenase Akt/PKB Colon cancer fetal bovine serum cancer stem cell phosphatase and tensin homolog phosphoinositide 3-kinase 5-fluorouracil BMP Drug resistance Neoplasia wild type reverse-transcription polymerase chain reaction Bone morphogenetic protein Secreted frizzled-related protein 4 Pten Colorectal glycogen synthase kinase bone morphogenetic protein receptor

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

Authors

Ylenia Lombardo, Alessandro Scopelliti, Patrizia Cammareri, Matilde Todaro, Flora Iovino, Lucia Ricci-Vitiani, Gaspare Gulotta, Francesco Dieli, Ruggero de Maria, Giorgio Stassi,