| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3295682 | Gastroenterology | 2011 | 11 Pages |
Abstract
IFN activates NK cells early after treatment is initiated. Their cytotoxic function, in particular, is strongly induced, which correlates to virologic response. Therefore, NK cell activation indicates responsiveness to IFN-α-based treatment and suggests the involvement of the innate immune cells in viral clearance.
Keywords
PBMCpegylated interferon-alfaPegIFNEVRRBVKirALTMFIAlanine aminotransferaseinterleukinLiver diseaseHCV treatmentRibavirinperipheral blood mononuclear cellsTRAILtumor necrosis factor–related apoptosis-inducing ligandCell deathmean fluorescence intensityResponse to Therapyearly virological responsekiller cell immunoglobulin-like receptors
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Authors
Golo Ahlenstiel, Birgit Edlich, Leah J. Hogdal, Yaron Rotman, Mazen Noureddin, Jordan J. Feld, Lauren E. Holz, Rachel H. Titerence, T. Jake Liang, Barbara Rehermann,