Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3295688 | Gastroenterology | 2011 | 14 Pages |
Abstract
MMP-9 mediates cellular inflammatory responses within the intestinal muscularis in mouse and rat models of POI. Inhibition of MMP-9 activity reduced recruitment of immune cells to the intestinal muscularis, preventing loss of smooth muscle contractility. Induction of MMP-9 expression requires inducible nitric oxide synthase.
Keywords
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Authors
Beverley A. Moore, Carl L. Manthey, Dana L. Johnson, Anthony J. Bauer,