| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3295698 | Gastroenterology | 2011 | 16 Pages |
Abstract
In obese, diabetic mice, hyperinsulinemia alters nuclear transcriptional regulators of cholesterol homeostasis, leading to hepatic accumulation of free cholesterol; the resulting cytotoxicity mediates transition of steatosis to NASH.
Keywords
ABCSREBPFXRscavenger receptor B1BSEPLRH-1ACATLDLRSHPSR-B1FFAHMGRCyPNAFLDadenosine triphosphate–binding cassette3-hydroxy-3-methyl-glutaryl-CoA reductasefarnesoid X receptorLiver Damagenonalcoholic steatohepatitisBile acidFree fatty acidIHCImmunohistochemistryNonalcoholic fatty liver diseaseLipotoxicityCytochrome P450small heterodimer partnerNash wild-typesterol regulatory element binding proteinBile salt export pumphigh-fatcholesteryl esterfree cholesterolLow-density lipoprotein receptor
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Authors
Derrick M. Van Rooyen, Claire Z. Larter, W. Geoffrey Haigh, Matthew M. Yeh, George Ioannou, Rahul Kuver, Sum P. Lee, Narci C. Teoh, Geoffrey C. Farrell,