Article ID Journal Published Year Pages File Type
3295700 Gastroenterology 2011 15 Pages PDF
Abstract
HBx mutants with changes that correspond to a combination of CP mutations up-regulate SKP2, which then down-regulates p21 via ubiquitin-mediated proteasomal degradation. CP mutations might increase the risk of hepatocellular carcinoma via this pathway.
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Health Sciences Medicine and Dentistry Gastroenterology
Preview
Hepatitis B Virus Core Promoter Mutations Contribute to Hepatocarcinogenesis by Deregulating SKP2 and Its Target, p21
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