| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3295706 | Gastroenterology | 2011 | 20 Pages |
Abstract
RelA/p65 functions in myeloid cells to promote pathogenesis of CP. In acinar cells, RelA/p65 protects against chronic inflammation, whereas myeloid RelA/p65 promotes fibrogenesis. In macrophage, MMP-10 functions as a RelA/p65-dependent, potentially antifibrogenic factor during progression of CP.
Keywords
TGF-βPDGFBMDMIKKECMECPIκBPSCMMP-10LoxPmRNAIκB kinase complexα-SMANF-κBmessenger RNAPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaElectrophoretic mobility shift assayα-smooth muscle actinTransforming growth factor βMicroarray analysistumor necrosis factor αPancreatic Stellate CellsEMSA یا electrophoretic mobility shift assay platelet-derived growth factorTNF-αnuclear factor κBExtracellular matrixBone marrow-derived macrophagesexpression profileImmune regulationinhibitor of κBchronic pancreatitisGenetics
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Authors
Matthias Treiber, Patrick Neuhöfer, Elisabeth Anetsberger, Henrik Einwächter, Marina Lesina, Mariana Rickmann, Song Liang, Timo Kehl, Hassan Nakhai, Roland M. Schmid, Hana Algül,