| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3295768 | Gastroenterology | 2010 | 20 Pages |
Abstract
These findings reveal a novel inhibitory interaction between TLR4 and NOD2 signaling in enterocytes leading to the regulation of enterocyte apoptosis and suggest a therapeutic role for NOD2 in the protection of intestinal diseases such as NEC.
Keywords
NECsecond mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pIMDPNOD2TLR4LPSRT-PCRGFPsodium dodecyl sulfate–polyacrylamide gel electrophoresisSDS-PAGENecrotizing enterocolitisinterleukinintestinal epithelial celllipopolysaccharideNitric oxidereverse-transcription polymerase chain reactiongreen fluorescent proteinIECToll-like receptor-4
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Authors
Ward M. Richardson, Chhinder P. Sodhi, Anthony Russo, Richard H. Siggers, Amin Afrazi, Steven C. Gribar, Matthew D. Neal, Shipan Dai, Thomas Jr, Maria Branca, Congrong Ma, John Ozolek, David J. Hackam,