| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3296104 | Gastroenterology | 2010 | 19 Pages |
Abstract
Thrombocytopenia exacerbates liver fibrosis; platelets have a previously unrecognized, antifibrotic role in suppressing type I collagen expression via the HGF-Met signaling pathway.
Keywords
TPOHGFα-SMAMMPPF4CREmRNAHSCs5-bromo-2-deoxyuridineECMBcl-2BDLmessenger RNASmall interfering RNAsiRNAT-BILALPAlkaline phosphataseα-smooth muscle actinBrdUterminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelingThrombopoietinTUNELApoptosisHepatic stellate cellsconditional knockoutHepatocyte growth factorPlatelet factor 4Extracellular matrixMatrix metalloproteasebile duct ligationtotal bilirubin
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Authors
Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Seiji Tadokoro, Akio Ido, Hirohito Tsubouchi, Norio Hayashi,