| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3296107 | Gastroenterology | 2010 | 12 Pages |
Abstract
The phosphoinositide 3-kinase pathway is important in the transdifferentiation of acinar cells to hepatocytes and those hepatocytes arise from acinar cells via ABCG2-expressing intermediates. Furthermore, ABCG2-expressing cells are multipotent and able to differentiate into hepatocytes and insulin-producing β cells.
Keywords
RT-PCRCYP3A1CCAAT enhancer binding protein βATP-binding cassette sub-family G member 2Carboxypeptidase AGLP-1eGFPOSMCyPABCG2PI3KDEXCPATransferrinc/ebpβTFnamylaseAMYoncostatin MTransdifferentiationbase pairDexamethasoneCytochrome P450phosphoinositide 3-kinaseMetaplasiaNicotinamidereverse-transcription polymerase chain reactionPancreasenhanced green fluorescent proteinPlasticityglucagon-like peptide 1NICGlutamine synthetase
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Authors
Sung-Yu Wu, Chi-Che Hsieh, Ruei-Ren Wu, Jimmy Susanto, Tsung-Ta Liu, Chia-Rui Shen, Yu Chen, Chien-Chang Su, Fang-Pei Chang, Hsiao-Min Chang, David Tosh, Chia-Ning Shen,