| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3296168 | Gastroenterology | 2011 | 21 Pages |
Abstract
Although Kras/KRAS mutation promotes serrated and hyperplastic morphologic features in colon epithelium, it is not able to initiate adenoma development, perhaps in part because activated Kras/KRAS signaling does not increase the number of presumptive stem cells in affected crypts.
Keywords
PI3KEYFPTCFERKeGFPHPPCDKMAPKOncogeneIHCimmunohistochemicalColorectal cancerColon cancerTumor suppressorT-cell factorphosphatidylinositol-3-kinaseMEKTransgenic miceenhanced yellow fluorescent proteinenhanced green fluorescent proteinmitogen-activated protein kinasemitogen-activated protein kinase kinasehyperplastic polypCRCextracellular signal-regulated kinasecyclin-dependent kinase
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Authors
Ying Feng, Guido T. Bommer, Jenny Zhao, Maranne Green, Evan Sands, Yali Zhai, Kelly Brown, Aaron Burberry, Kathleen R. Cho, Eric R. Fearon,