| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3296175 | Gastroenterology | 2011 | 18 Pages |
Abstract
K8 can undergo conformational changes from predominantly α-helical to cross β-sheet, which would allow it to form MDBs. These findings might account for the observation that krt8â/â mice do not form MDBs, whereas its excess facilitates MDB formation. LCOs might be used in diagnosis of liver disorders; they can be applied to formalin-fixed, paraffin-embedded tissues to characterize protein aggregates in liver cells.
Keywords
BSOα1-ATIHBMallory–Denk bodyα1-antitrypsinLCPLCOp62MDBK183,5-diethoxycarbonyl-1,4-dihydrocollidineddCFFPEt-BHPalcoholic steatohepatitisnonalcoholic steatohepatitisbuthionine sulfoximineLiver diseaseprotein aggregationAshintermediate filamentformalin-fixed and paraffin-embeddedNash Keratinkeratin 18keratin 8
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Authors
Vineet Mahajan, Therése Klingstedt, Rozalyn Simon, K. Peter R. Nilsson, Andrea Thueringer, Karl Kashofer, Johannes Haybaeck, Helmut Denk, Peter M. Abuja, Kurt Zatloukal,