Losartan Prevents Portal Hypertension-Induced, Redox-Mediated Endothelial Dysfunction in the Mesenteric Artery in Rats

CBDL is associated with reduced EDHF-mediated relaxations in the mesenteric artery, whereas NO-mediated relaxations persisted. These findings indicate that impaired EDHF-mediated relaxation involves an excessive vascular oxidative stress, most likely following activation of angiotensin II type 1 receptors.