Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3296847 | Gastroenterology | 2010 | 16 Pages |
Abstract
T-cell exhaustion by high antigen concentrations promotes HBV-specific T-cell dysfunction by affecting phenotype and function of peripheral and intrahepatic T cells. By restoring antiviral T-cell functions, not only in peripheral but also in intrahepatic lymphocytes, anti-PD-L1 might be a good therapeutic candidate for chronic HBV infection.
Keywords
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Authors
Paola Fisicaro, Caterina Valdatta, Marco Massari, Elisabetta Loggi, Elisabetta Biasini, Luca Sacchelli, Maria Cristina Cavallo, Enrico M. Silini, Pietro Andreone, Gabriele Missale, Carlo Ferrari,