| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3296849 | Gastroenterology | 2010 | 14 Pages |
Abstract
Liver fibrosis is regulated by an epigenetic relay pathway that includes MeCP2, EZH2, and miR132. Reagents that interfere with this pathway might be developed to reduce fibrogenesis in chronic liver disease.
Keywords
HSCCREBqPCRPRC2TGFβ1TIMP-1Mecp2BDLCCl4PPARγSmall interfering RNAsiRNAsodium dodecyl sulfate–polyacrylamide gel electrophoresisSDS-PAGEchromatin immunoprecipitationtissue inhibitor of metalloproteinase-1Transforming growth factor β1Reverse transcriptaseHepatic stellate cellUTR یا untranslated regions untranslated regionwild-typequantitative polymerase chain reactionmethyl-CpG binding protein 2bile duct ligationCHiPCarbon tetrachloridePeroxisome proliferator-activated receptor-γ
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Authors
Jelena Mann, David C.K. Chu, Aidan Maxwell, Fiona Oakley, Nian-Ling Zhu, Hidekazu Tsukamoto, Derek A. Mann,