| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3297108 | Gastroenterology | 2009 | 16 Pages |
Abstract
PTPN2 is activated by IFN-γ and limits IFN-γ-induced signalling and consequent barrier defects. These data suggest a functional role for PTPN2 in maintaining the intestinal epithelial barrier and in the pathophysiology of CD.
Keywords
AMPKAICARTNFTC-PTPFITCmRNAPTPN2IFN-γPTPIBDmessenger RNASmall interfering RNAsiRNASTATinterferon γCrohn's diseaseInflammatory bowel diseasecompound CTERIntestinal epithelial cellstumor necrosis factorfluorescein isothiocyanateSignal transducer and activator of transcriptiontransepithelial electrical resistanceT-cell protein tyrosine phosphataseProtein tyrosine phosphataseadenosine monophosphate-activated protein kinaseSingle nucleotide polymorphismSNPIECUlcerative colitis
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Authors
Michael Scharl, Gisela Paul, Achim Weber, Barbara C. Jung, Michael J. Docherty, Martin Hausmann, Gerhard Rogler, Kim E. Barrett, Declan F. McCole,