| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3297263 | Gastroenterology | 2011 | 11 Pages |
Abstract
TG2 and TG activity are up-regulated during hepatic fibrosis progression, but do not contribute to fibrogenesis or stabilization of the collagen matrix. TG2 deletion does not promote regression of liver fibrosis. TG2-independent collagen cross-linking is a remarkable feature of progressing hepatic fibrosis and represents an important therapeutic target for liver fibrosis.
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Authors
Yury Popov, Deanna Y. Sverdlov, Anisha K. Sharma, K. Ramakrishnan Bhaskar, Shaoyong Li, Tobias L. Freitag, James Lee, Walburga Dieterich, Gerry Melino, Detlef Schuppan,