Angiotensin II Activates IÎºB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis

Article ID	Journal	Published Year	Pages	File Type
3297336	Gastroenterology	2009	12 Pages	PDF

Abstract

An autocrine pathway that includes angiotensin II, IKK, and P-Ser536-RelA regulates myofibroblast survival and can be targeted to stimulate therapeutic regression of liver fibrosis.

Keywords

NF-κB α-SMA ACE IκB AT1 IKK IκB kinase angiotensin converting enzyme angiotensin type 1 receptor Smooth muscle α-actin nuclear factor-κB inhibitor of NF-κB

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Angiotensin II Activates IÎºB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis

Authors

Fiona Oakley, Victoria Teoh, Gemma Ching-A-Sue, Ramon Bataller, Jordi Colmenero, Julie R. Jonsson, Aristides G. Eliopoulos, Martha R. Watson, Derek Manas, Derek A. Mann,