Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3297414 | Gastroenterology | 2011 | 19 Pages |
Abstract
Bacterial infection and PGE2 signaling are required for gastric tumorigenesis in mice; they cooperate to up-regulate CCL2, which recruits macrophage to gastric tumors. Macrophage-derived tumor necrosis factor-α promotes Wnt signaling in epithelial cells, which contributes to gastric tumorigenesis.
Keywords
NF-κBGermfreeLPSIL-6mPGES-1SPFGaNCOX-2RT-PCRIL-1βPGE2Tumor promotioninterleukin-6Interleukin-1βTAMtumor necrosis factor-αStomach cancerCyclooxygenase-2Bacterial infectionTNF-αnuclear factor-κBlipopolysaccharideTumor-associated macrophagereverse transcription-polymerase chain reactionspecific pathogen freemicrosomal prostaglandin E synthase-1Prostaglandin E2
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Authors
Hiroko Oshima, Kyoji Hioki, Boryana K. Popivanova, Keisuke Oguma, Nico Van Rooijen, Tomo-O. Ishikawa, Masanobu Oshima,