| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3297424 | Gastroenterology | 2011 | 16 Pages |
Abstract
Type I IFNs have anti-inflammatory effects mediated by endogenous IL-1ra, which regulates the extent of TLR9-induced liver damage. Type I IFN signaling is therefore required for protection from immune-mediated liver injury.
Keywords
IL-1RATNFIFNAR1pegylatedISGIRFLTATLRCpGLPSBacterial DNAInterleukin 1 receptor antagonistlipoteichoic acidInnate immunityImmunologyinterferonIFNLiver diseaseEnzyme-linked immunosorbent assayELISAToll-like receptorinterferon regulatory factortumor necrosis factorlactate dehydrogenaseLDHlipopolysaccharidewild-typepolymerase chain reactionPCRPEGinterferon-stimulated genetype I interferon receptor
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Authors
Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn A. Kurt-Jones, Gyongyi Szabo,