| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3297425 | Gastroenterology | 2011 | 21 Pages |
Abstract
ACV-TP-T, a thymidine analogue that is metabolized by telomerase and releases the active form of acyclovir, reduces proliferation and induces apoptosis of human pancreatic cancer cell lines in vitro and pancreatic xenograft tumors in mice.
Keywords
T/CPCNAIC50GCVALTACVhTERTSmall interfering RNAsiRNAAcyclovirProliferating Cell Nuclear AntigenImmunohistochemistryIHCBrdUbromodeoxyuridineTelomerehuman telomerase reverse transcriptaseSuicide gene therapyAlternative lengthening of telomereshalf maximal inhibitory concentrationThymidine kinase geneGanciclovir
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Simone Polvani, Massimo Calamante, Valeria Foresta, Elisabetta Ceni, Alessandro Mordini, Alessandro Quattrone, Massimo D'Amico, Claudio Luchinat, Ivano Bertini, Andrea Galli,