| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3297713 | Gastroenterology | 2010 | 15 Pages |
Abstract
H pylori is able to inhibit the tumor suppressor p53. H pylori activates AKT1, resulting in phosphorylation and activation of HDM2 and subsequent degradation of p53 in gastric epithelial cells. H pylori-induced dysregulation of p53 is a potential mechanism by which the microorganism increases the risk of gastric cancer in infected individuals.
Keywords
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Gastroenterology
Authors
Jinxiong Wei, Toni A. Nagy, Anna Vilgelm, Elena Zaika, Seth R. Ogden, Judith Romero-Gallo, Maria B. Piazuelo, Pelayo Correa, Mary K. Washington, Wael El-Rifai, Richard M. Peek, Alexander Zaika,