| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3297853 | Gastroenterology | 2009 | 13 Pages |
Abstract
These results showed that histidine could be a novel therapeutic agent for CD by inhibition of NF-κB activation, following down-regulation of proinflammatory cytokine production by macrophages. Thus, our studies provided new insights into the roles of amino acid metabolism in the pathophysiology of CD and for therapeutic strategies.
Keywords
LPSMCPMIPGAPDHPBMCsHDCMLNCrohn's diseaseelemental dietTIMPLamina Propria Mononuclear Cellsperipheral blood mononuclear cellslipopolysaccharidetissue inhibitors of matrix metalloproteinaseHistidine Decarboxylasemacrophage inflammatory proteinmonocyte chemoattractant proteinKeratinocyte chemoattractantmesenteric lymph nodeglyceraldehyde-3-phosphate dehydrogenase
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Authors
Ayatoshi Andou, Tadakazu Hisamatsu, Susumu Okamoto, Hiroshi Chinen, Nobuhiko Kamada, Taku Kobayashi, Masaki Hashimoto, Tomohisa Okutsu, Kazutaka Shimbo, Tomoko Takeda, Hideki Matsumoto, Atsushi Sato, Hiroshi Ohtsu, Manabu Suzuki, Toshifumi Hibi,