Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3298730 | Gastroenterology | 2009 | 11 Pages |
Abstract
Glutamine induces autophagy under basal and stressed conditions, and prevents apoptosis under heat stress through its regulation of the mTOR and p38 MAP kinase pathways. We propose that glutamine contributes to cell survival during physiologic stress by induction of autophagy.
Keywords
TBSTTRIS-buffered saline with Tweenp70 S6 kinaseS6KBBESAPKPARPDMEMLC3HspTBSmTORDulbecco's modified Eagle Mediumshort interfering RNAsiRNATris-buffered salinemicrotubule-associated protein light chain 3intestinal epithelial cellmapmammalian target of rapamycinHeat shock proteinmitogen-activated proteinStress-activated protein kinasepoly (ADP-ribose) polymeraseIEC
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Authors
Toshio Sakiyama, Mark W. Musch, Mark J. Ropeleski, Hirohito Tsubouchi, Eugene B. Chang,