| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3298883 | Gastroenterology | 2009 | 12 Pages |
Abstract
β-catenin/TCF4 regulates cell cycle promoting (c-MYC, CYCLIN D1) and inhibiting genes (p16INK4A) at the same time in the mesenchymally differentiated tumor cells at the front of invasion. The function of p16INK4A seems to supersede in this context thus leading to low proliferation. Moreover, these tumor cells seem to govern the outcome of colorectal cancer independently of their proliferation.
Keywords
TBEMethylated DNATFIIBHprtMSPCBPAPCETsqRT-PCRCREBGFPACFGSTGAPDHINK4quantitative RT-PCRadenomatous polyposis colielectromobility shift assaycAMP response element-bindingReverse transcriptaseEMTmutatedDouble strandedColorectal cancerEMSA یا electrophoretic mobility shift assay dominant negativeaberrant crypt fociwild-typeCREB-binding proteingreen fluorescent proteinHATglutathione-S-transferase
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Authors
Stella Wassermann, Silvio K. Scheel, Elke Hiendlmeyer, Richard Palmqvist, David Horst, Falk Hlubek, Angela Haynl, Lydia Kriegl, Simone Reu, Susanne Merkel, Thomas Brabletz, Thomas Kirchner, Andreas Jung,