| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3298893 | Gastroenterology | 2009 | 14 Pages |
Abstract
CT induces specific and sustained hyperexcitability of secretomotor neurons in enteric pathways. CT acts in the mucosa. Its effect is neurally mediated and depends on 5-hydroxytryptamine-3, nicotinic, and NK1 receptors. This system represents a unique model to understand the neural mechanisms of action of CT and to identify therapeutic targets.
Keywords
VIPCT-BPPADSEPSPsENSafter hyperpolarizationIPSPsCFTRTTXNPYAPsAChAcetylcholinesubmucosal plexustetrodotoxinSMPcystic fibrosis transmembrane conductance regulatorcholera toxinenteric nervous systeminput resistanceneurokinin action potentialsexcitatory postsynaptic potentialsinhibitory postsynaptic potentialsvasoactive intestinal peptideNeuropeptide Y
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Authors
Rachel M. Gwynne, Melina Ellis, Henrik Sjövall, Joel C. Bornstein,