| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3302512 | Gastrointestinal Endoscopy | 2015 | 12 Pages |
BackgroundSelf-expandable metal stent (SEMS) placement and palliative gastrojejunostomy (GJJ) are palliative treatment options for malignant gastric outlet obstruction.ObjectiveTo compare clinical outcomes of palliative treatments for gastric outlet obstruction caused by unresectable gastric cancer.DesignRetrospective study.SettingUniversity-affiliated tertiary-care hospital in the Republic of Korea.PatientsTwo hundred fifty-six patients with gastric outlet obstruction caused by unresectable gastric cancer.InterventionSEMS placement and palliative GJJ.Main Outcome MeasurementsPatency duration and overall survival duration.ResultsIn total, 217 and 39 patients underwent SEMS placement and palliative GJJ, respectively, as an initial palliative treatment. Treatment modality affected reobstruction after clinical success (hazard ratio [HR] [95% confidence interval {CI}], 0.5 [0.3–0.8] of palliative GJJ). In addition, carcinomatosis with ascites was an independent associated factor of clinical success and reobstruction (HR [95% CI], 0.3 [0.1–0.7] and 1.4 [1.0–2.0], respectively). In a subgroup of patients with good performance who had neither carcinomatosis nor ascites, patency duration and overall survival duration did not differ between the 2 groups (P = .079 and P = .290, respectively). In patients with good performance who had carcinomatosis without ascites, patency duration was longer in the palliative GJJ group than in the SEMS placement group (P = .016). Overall survival, however, did not differ between the 2 groups (P = .062). In a subgroup of patients with good performance who had carcinomatosis with ascites, both patency duration and overall survival were longer in the palliative GJJ group than in the SEMS placement group (P = .007 and P = .012, respectively).LimitationsNonrandomized, retrospective study.ConclusionLong-term clinical outcomes of the palliative treatment modality for gastric outlet obstruction caused by unresectable gastric cancer were affected by carcinomatosis and ascites status.
