| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 330332 | Neurobiology of Aging | 2009 | 5 Pages |
Abstract
Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5′ sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Julien Chapuis, Maud Boscher, Faiza Bensemain, Dominique Cottel, Philippe Amouyel, Jean-Charles Lambert,