Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
330357 | Neurobiology of Aging | 2008 | 4 Pages |
Abstract
There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case–control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Shangxi Xiao, Christine Sato, Toshitaka Kawarai, Emily F. Goodall, Hardev S. Pall, Lorne H. Zinman, Janice Robertson, Karen Morrison, Ekaterina Rogaeva,