| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3303972 | Gastrointestinal Endoscopy | 2010 | 4 Pages |
BackgroundAblative therapies such as radiofrequency and cryotechnology are widely used in oncological intervention but not in the pancreatic field because of their high operative risks. A new flexible bipolar ablation device (Cryotherm probe [CTP]) was developed combining radiofrequency and cryotechnology.ObjectiveTo evaluate the efficacy of the CTP in destroying neoplastic tissue of explanted pancreatic tumors of patients with pancreatic adenocarcinoma.DesignEx vivo clinical study.SettingInpatient hospital setting.PatientsThis study involved 16 explanted pancreatic tumors from 16 patients.InterventionsCTP application was performed on explanted pancreatic tumors. Anatomic specimens were divided into 4 groups; each group received a predefined application time of 120 to 600 seconds.Main Outcome MeasurementsThe coagulation diameter (short axis) perpendicular to the device's longitudinal axis was used as the primary outcome measure.ResultsAll pancreatic specimens showed histological signs of coagulative necrosis. There was a positive correlation between the short axis of the obtained necrosis and duration of application (r = 0.74).LimitationsThis study was an ex vivo study with all limitations typical of this kind of study.ConclusionsThe CTP is effective in destroying neoplastic pancreatic tissue, creating an ablation zone, the extent of which is related to the duration of application.
