| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3305836 | Gastrointestinal Endoscopy | 2011 | 10 Pages |
BackgroundMissing adenomas and the inability to accurately differentiate between polyp histology remain the main limitations of standard-definition white-light (SD-WL) colonoscopy.ObjectiveTo compare the adenoma detection rates of SD-WL with those of high-definition white-light (HD-WL) and narrow-band imaging (NBI) as well as the accuracy of predicting polyp histology.DesignMulticenter, prospective, randomized, controlled trial.SettingTwo academic medical centers in the United States.PatientsSubjects undergoing screening or surveillance colonoscopy.InterventionSubjects were randomized to undergo colonoscopy with one of the following: SD-WL, HD-WL, or NBI.Main Outcome MeasurementsThe proportion of subjects detected with adenomas, adenomas detected per subject, and the accuracy of predicting polyp histology real time.ResultsA total of 630 subjects were included. The proportion of subjects with adenomas was 38.6% with SD-WL compared with 45.7% with HD-WL and 46.2% with NBI (P = .17 and P = .14, respectively). Adenomas detected per subject were 0.69 with SD-WL compared with 1.12 with HD-WL and 1.13 with NBI (P = .016 and P = .014, respectively). HD-WL and NBI detected more subjects with flat and right-sided adenomas compared with SD-WL (all P values <.005). NBI had a superior sensitivity (90%) and accuracy (82%) to predict adenomas compared with SD-WL and HD-WL (all P values <.005).LimitationsAcademic medical centers with experienced endoscopists.ConclusionsThere was no difference in the proportion of subjects with adenomas detected with SD-WL, HD-WL, and NBI. However, HD-WL and NBI detected significantly more adenomas per subject (>60%) compared with SD-WL. NBI had the highest accuracy in predicting adenomas in real time during colonoscopy. (Clinical Trial registration number: NCT 00614770.)
