Carbon dioxide versus room air for natural orifice transluminal endoscopic surgery (NOTES) and comparison with standard laparoscopic pneumoperitoneum

Pressure-controlled endoscopic insufflation of CO2 for NOTES showed minor advantages compared with insufflation of room air regarding intra-abdominal visualization, but resulted in an increase in cardiac afterload. However, the cardiorespiratory responses during endoscopic insufflation of CO2 were similar to the widely accepted standard laparoscopic CO2 insufflation.