Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
331327 | Neurobiology of Aging | 2006 | 5 Pages |
Abstract
Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status.
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Authors
Edmund C. Jenkins, Milen T. Velinov, Lingling Ye, Hong Gu, Shuyun Li, Edmund C. Jenkins Jr., Susan Sklower Brooks, Deborah Pang, Darlynne A. Devenny, Warren B. Zigman, Nicole Schupf, Wayne P. Silverman,