| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3313542 | Journal of Hepatology | 2016 | 13 Pages |
Abstract
SummaryDuring hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately determines HBV infection outcome. In this review, in addition to summarizing the present state of knowledge of HBV-adaptive immunity, we will highlight controversies and uncertainties concerning the HBV-specific B and T lymphocyte response, and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.
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Authors
Antonio Bertoletti, Carlo Ferrari,