| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3314651 | Journal of Hepatology | 2007 | 8 Pages |
Abstract
In cirrhosis GLUT4 protein content was quantitatively intact, while limiting glucose tolerance. This indicates loss of redundancy of the major glucose transport system, possibly related to the markedly decreased expression of its gene. Hyper-insulinemia may be a primary event. Our findings implicate the muscular GLUT4 system in the glucose intolerance of liver cirrhosis by a mechanism different from that in diabetes.
Keywords
GLUT4galactose elimination capacityGECNGTOGTTRT-PCRIGTOral glucose tolerance testimpaired glucose toleranceHomeostasis model assessmentClinical researchanalysis of varianceANOVAnormal glucose toleranceDiabetes mellitusliver cirrhosisGlucose intoleranceSkeletal muscleconfidence intervalInsulin resistanceHOMAreverse transcriptase polymerase chain reaction
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Authors
Peter Holland-Fischer, Per Heden Andersen, Sten Lund, Steen Bønnelykke Pedersen, Lars Vinter-Jensen, Michael F. Nielsen, Andreas Kaal, Rolf Dall, Ole Schmitz, Hendrik Vilstrup,